DR. ROLIKA BANSAL

Dr. SANTOSH G. HONAVAR

Abstract

Purpose To assess the efficacy and outcomes of secondary triple drug super-selective ophthalmic artery intra-arterial chemotherapy(IAC) in advanced and refractory intraocular retinoblastoma.

Methods: A retrospective, consecutive, case series of advanced retinoblastoma

Results: 61 eyes of 58 patients received secondary IAC (mean number of cycles 2.5), primarily treated with intra-venous chemotherapy (IVC) &/or focal treatment. Baseline grouping was group D 16(26%), group E 28(46%) and 17(28%) were treated elsewhere. Globe salvage was achieved in 33(54%) [group D 10(62%, n=16), group E 13(46%, n=28), elsewhere treated 10(59%, n=17] at a follow up of 40.3+25.4 m(range 7-84 m) with life salvage in 60 (98%) patients while one succumbed to non-treatment related causes.

Conclusion: Secondary IAC following primary IVC & focal treatment has high globe salvage & life salvage rates. In developing countries, secondary IAC may be followed instead of primary IAC to make the treatment cost-effective

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