Dr. NITHIN KESHAV SRINIVASAN

DR. NAVEEN KESHAV S

Abstract

45 year old lady presented with bilateral blurring of vision. Visual acuity was 6/7.5 in right & 6/9 in left. Fundus showed presence of vitreous cells in both eyes. OCT revealed thickened choroid in both eyes and serous retinal detachments. FA showed diffuse leakage at macula in both eyes. History revealed a recent diagnosis of Acute Lymphoblastic Leukemia. Started on chemotherapy and symptoms subsided. 3 years later presented with redness in right eye. 2mm white hypopyon with a tinge of hemorrhage noted. Vision 6/6p in both eyes. Aqueous tap was sent for histopathology, PAP stain showed increase in lymphoid cells. C79a (b cell marker) and Ki67 marker for proliferation increased by 75%. MRI Brain was suggestive of relapse of CNS leukemia. Leukemic cell infiltration or hematologic disturbances may cause partial occlusion of the choriocapillaries and delay of choroidal circulation. Secondary dysfunction of the Bruch’s membrane and RPE leads to serous retinal detachments of the macula.