DR. TRISHA GHOSH

DR. SANJAY KUMAR DAULAT THAKUR, DR. PRATIROOP GANGOPADHYAY

Abstract

Aim: To assess the role of inflammation in the pathogenesis of diabetic retinopathy using the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and mean platelet volume (MPV).

Methods: A cross sectional study was conducted among 60 patients with definite diagnosis of type 2 DM attending Ophthalmology OPD of a tertiary care hospital. We obtained blood samples from all patients who participated in the study to investigate these parameters.

Results: 60 subjects were included in this study: 30 in the DR group and 30 in the NDR group. The mean NLR, PLR, and MPV levels were higher in DR group than in NDR group(NLR: 2.49+0.82 in DR group vs 1.94+0.75 in NDR group, p=0.003; PLR : 114.88+5.48 in DR group vs 104.5+6.73 in NDR group, p=0.01; MPV: 11.08+1.21 in DR group vs 9.92+1.62 in NDR group, p=0.003).

Conclusion: The higher NLR, PLR, and MPV levels found in patients with DR may indicate that subclinical systemic inflammation may be associated with DR.